News

Cyclarity Therapeutics Announces Clinical Advisory Board

by

Press Release

NOVATO, Calif., October 17, 2023 (GLOBE NEWSWIRE)

Cyclarity Therapeutics, Inc.  today announced its newly formed Clinical Advisory Board to guide its clinical development of drug candidate UDP-003 for the treatment and prevention of atherosclerosis, primary coronary artery disease, and associated cardiovascular diseases.

The Board includes the internationally recognized, preeminent cardiologists:

Dr. Prediman K. Shah, Director of Inpatient Cardiology and the Coronary Care Unit at Cedars-Sinai Hospital, Founder and Director of the Oppenheimer Atherosclerosis Research Center at Cedars-Sinai Hospital.

Dr. Michael E. Farkouh, Associate Dean for Research and Clinical Trials and Professor of Cardiology at Cedars-Sinai Hospital.

Dr. Stephen Nicholls, Program Director of MonashHeart, Intensive Care and Victorian Heart Hospital, Monash Health, as well as Director of the Monash Victorian Heart Institute and Professor of Cardiology at Monash University.

Read the Press Release

“It’s an honor to have Drs. Nicholls, Farkouh and Shah working with us to provide strategic guidance over the preparation and execution of our clinical program,” said Mike Kope, Corporate Affairs CEO of Cyclarity. Cyclarity expects to conduct the UDP-003 Phase 1 trial under the direction of Dr. Nicholls and VHI, and is exploring potential lead site and primary PI roles with Drs. Farkouh and Shah at Cedars-Sinai.

“We are especially encouraged by the interest of this distinguished Board not only in our drug candidate, but in the novel target we are addressing,” noted Matthew O’Connor, Cyclarity’s Scientific Affairs CEO. “Their guidance will provide immeasurable assistance to our evaluation of outcomes and our examination of oxidized cholesterols as causative biomarkers of atherosclerosis.”

About Cyclarity Therapeutics, Inc.

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Our latest manuscript pre-proof in Carbohydrate Polymers

by

Pre-proofs are now available for our latest manuscript in Carbohydrate Polymers: “Addressing the complexities in measuring cyclodextrin-sterol binding constants: A multidimensional study”.

Abstract:

Cyclarity Therapeutics has developed a new class of cyclodextrin (CD) dimers as a potential new treatment for atherosclerosis. These CD therapies work by forming strong, soluble inclusion complexes with oxysterols, allowing the body to reduce and heal arterial plaques. However, characterizing the interactions between CD dimers and oxysterols presents formidable challenges due to low sterol solubility, the synthesis of modified CDs resulting in varying number and position of molecular substitutions, and the diversity of interaction mechanisms. To address these challenges and illuminate the nuances of CD-sterol interactions, we have used multiple orthogonal approaches for a comprehensive characterization. Results obtained from three independent techniques – metadynamics simulations, competitive isothermal titration calorimetry, and circular dichroism – to quantify CD-sterol binding are presented. The objective of this study is to obtain the binding constants and gain insights into the intricate nature of the system, while accounting for the advantages and limitations of each method. Notably, our findings demonstrate ~1000× stronger affinity of the CD dimer for 7-ketocholesterol in comparison to cholesterol for the 1:1 complex in direct binding assays. These methodologies and findings not only enhance our understanding of CD dimer-sterol interactions, but could also be generally applicable to prediction and quantification of other challenging host-guest complex systems.

Congratulations to our team and collaborators – great work!

Read the Pre-Proof

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Dr. Oki O’Connor talks with Phil Newman of Longevity.Technology about Cyclarity’s solution

by

Watch the Longevity.Technology interview of Dr. Oki O’Connor on “Cyclarity’s elegant solution to one of the world’s biggest problems – atherosclerosis.” 

Dr. O’Connor and Phil Newman discuss:

  • The unique Cyclarity platform.
  • The nature of cyclodextrins.
  • The opportunities in the cyclodextrin market.
  • The size of the problem.

We’re thrilled to be working towards reversing the world’s leading killer and thankful to Longevity.Technology for bringing a focus to our novel treatment.

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Congratulations to our talented team on their larger roles in developing cures for heart disease!

by

Congratulations to our diligent and talented team members who are taking on larger roles as we develop our novel technologies to cure atherosclerosis!

  • Dr. Daniel Clemens: Vice President of Biology
  • Dr. Keivan Sadrerafi: Director of Chemistry
  • Dr. Prerna Bhargava: Senior Scientist
  • Darren Dinh: Senior Research Associate/ Lab Manager

It is through the hard work of our dedicated team that we are able to take on the world’s leading killer!

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Longevity.Technology publishes report on atherosclerosis and Cyclarity’s novel approach

by

We invite you to read the Longevity.Technology report “Disease management to disease modification – removing plaque to undo atherosclerosis”.

This detailed report highlights:

  • Atherosclerosis disease profile – accounting for over 40% of all deaths worldwide.
  • Current treatments that fail to address the underlying cause of the disease, or reverse the atherosclerotic plaques already formed. 
    Cyclarity’s novel “disease-modifying” solution to repair an underlying cause of many age related diseases, removing toxic biomolecules from inside cells.
  • Cyclarity’s primary candidate, UDP-003 a beta-cyclodextrin designed to target and remove toxic, oxidized cholesterol.
  • The potential promise for investors, healthcare systems in the US and globally, and, most of all, for those affected by atherosclerosis-related disease.
The report concludes:

Cyclarity’s approach to true disease medication, and therefore reversal of age-related disease, without doubt, offers a great deal of promise for investors, for healthcare systems in the US and globally, and most of all for those affected by atherosclerosis-related disease.

. . . this may be the perfect opportunity for Cyclarity to enter the field, as it is one of the few solutions available that addresses the limiting factors of previous therapies both from a scientific perspective and from a market perspective.

We’re thrilled to be working towards reversing the world’s leading killer and thankful to Longevity.Technology for bringing a focus to our novel treatment.

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.underdogpharma.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Mike Kope talks with Phil Newman of Longevity.Technology about Cyclarity

by

Watch Cyclarity CEO of Corporate Affairs Mike Kope talk with Phil Newman of Longevity.Technology about tackling oxidized cholesterol and taking on the world’s biggest killer.

You can read more HERE at Longevity.Technology.

 

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Mike Kope presents at the Rejuvenation Startup Summit 2022

by

Watch Cyclarity’s CEO of Corporate Affairs Mike Kope discuss company strategy and the work to prevent age-related conditions such as atherosclerosis, heart attack, and stroke by addressing the root cause at the Rejuvenation Startup Summit 2022.

Thanks to Forever Healthy Foundation, KIZOO Technology Capital, Frank Schueler & Michael Greve for an amazing inaugural event.

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Cyclarity Therapeutics has Moved to the Buck Institute for Research on Aging

by

Press Release

Novato, CA, U.S., June 24, 2022 – Announcing our move to the Buck Institute for Research on Aging.

Cyclarity Therapeutics (https://cyclaritytx.com) has just completed the move of its research and operations to the state-of-the-art labs at the Buck Institute for Research on Aging. We presented the progress of our lead program to the President and Senior Officers of the Buck Institute earlier this year, and they kindly extended an offer of tenancy. 

Our relationship with the Buck Institute offers not only access to a variety of important core facilities; we expect it offers a wonderful opportunity to expand our collaborations and relationships with many world leaders in cardiovascular disease, and the field of aging as a whole.

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Underdog Pharmaceuticals has changed its name to Cyclarity Therapeutics

by

Press Release

Novato, CA, U.S., June 24, 2022 – Announcing our corporate name change and new branding.

We’re excited to announce that Underdog Pharmaceuticals has changed its name to Cyclarity Therapeutics.

We remain exactly on track to commence human clinical trials for UDP-003 in 2023. Now at the halfway point of 2022, the closer we get to this critical goal, the more exciting things have become here. Unfortunately, it has raised one significant problem for us:

In the race to cure atherosclerosis, it’s getting hard to refer to ourselves as the “Underdog!”

So we met with the Board, talked to select stakeholders and PR professionals (and a lawyer or two), and asked our shareholders to approve a new corporate name, the brand under which our team will strive to cure heart disease and to make our mark in the field of aging. We strove to connote vision, and to reference the clearance of toxic oxysterols and other by-products of aging that will remain our focus. So, welcome, all, to Cyclarity.

We have been fortunate to have the unwavering support of Kizoo Technology Ventures as our lead investor, and all of your support as our shareholders, collaborators and friends. Your clarity of vision helped get us this far, and we look forward now, with Cyclarity, to the commencement of human trials for what may be one of the most important rejuvenation drugs in development. Thank you.

About Cyclarity

Cyclarity Therapeutics, Inc., is pursuing a mission to treat the underlying causes of age-related disease. The company develops simple and direct interventions targeting oxidized cholesterol using rationally designed molecules, to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke. Its products are based on novel derivatives of a well-known, safe compound and a new way of looking at cardiovascular disease. For more information, please visit www.cyclaritytx.com or send an email to press@cyclaritytx.com

Forward Looking Statements

The information and statements contained herein contain forward-looking statements, which are subject to risks and uncertainties that could cause actual results to differ materially from such forward-looking statements and should not be considered as an indication or guarantee of future performance. Forward-looking statements involve known and unknown risks and uncertainties which could cause the Company’s prospects or actual results to differ materially from those in the forward-looking statements. The Company does not undertake any obligation to update the information or forward-looking statements contained herein whether as a result of new information or future events or otherwise.

Contact:

Mike Kope
CEO of Corporate Affairs
Cyclarity Therapeutics, Inc.
press@cyclaritytx.com

Cyclarity Therapeutics logos for media use:

PNG-Raster​
CMYK-EPS-Vector​

KIZOO Technology Capital owner Michael Greve discusses recent scientific advancements with Drug Discovery World

by

KIZOO Technology Capital owner Michael Greve discusses the recent scientific advancements in addressing the root causes of age-related diseases in the rejuvenation biotechnology sphere—including the work of Underdog Pharmaceuticals. As one of Kizoo’s key startups, Underdog’s goal is to deliver affordable therapeutics for the prevention of heart disease and stroke through the removal of arterial plaque.

Read the article

Media Contact for Kizoo:

Frank Schueler
Managing Director
Kizoo Technology Capital
fs@kizoo.com

Media Contact for Underdog:

Mike Kope
Co-CEO
Underdog Pharmaceuticals Inc
press@cyclaritytx.com

Contact
Linkedin-in Facebook-f Twitter Instagram

© 2023 Cyclarity Therapeutics – ALL RIGHTS RESERVED

Site developed by Moonburn.com

Terms of Use | Privacy Policy

Contact
Linkedin-in Facebook-f Twitter Instagram

© 2023 Cyclarity Therapeutics – ALL RIGHTS RESERVED

Terms of Use  | Privacy Policy

Site developed by Moonburn.com